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Optical Engineering

Tissue characterization and imaging using photon density waves
Author(s): Lars Othar Svaasand; Bruce J. Tromberg; Richard Campbell Haskell; Tsong-Tseh Tsay; Michael W. Berns
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Paper Abstract

The optical properties of brain tissues have been evaluated by measuring the phase velocity and attenuation of harmonically modulated light. The phase velocity for photon density waves at 650-nm wavelength has been found to be in the range of 5 to 12% of the corresponding velocity in a nonscattering medium, and the optical penetration depth was in the range 2.9 to 5.2 mm. These results are used to predictthe resolution of optical imaging of deep tissue structures by diffusely propagating incoherent photons. The results indicate that structures of a few millimeters in linear dimension can be identified at 10 mm depth provided that proper wavelength and time resolution are selected. This depth can possibly be enlarged to 30 mm in the case of tissues with very low scattering such as in the case of the neonatal human brain.

Paper Details

Date Published: 1 February 1993
PDF: 9 pages
Opt. Eng. 32(2) doi: 10.1117/12.60749
Published in: Optical Engineering Volume 32, Issue 2
Show Author Affiliations
Lars Othar Svaasand, Univ. of Trondheim (Norway)
Bruce J. Tromberg, Univ. of California/Irvine (United States)
Richard Campbell Haskell, Harvey Mudd College (United States)
Tsong-Tseh Tsay, Univ. of California/Irvine (United States)
Michael W. Berns, Univ. of California/Irvine (United States)

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