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Journal of Biomedical Optics

Light propagation in tissues with controlled optical properties
Author(s): Valery V. Tuchin; Irina L. Maksimova; Dmitry A. Zimnyakov; Irina L. Kon; Albert H. Mavlyutov; Alexey A. Mishin
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Paper Abstract

Theoretical and computer modeling approaches, such as Mie theory, radiative transfer theory, diffusion wave correlation spectroscopy, and Monte Carlo simulation were used to analyze tissue optics during a process of optical clearing due to refractive index matching. Continuous wave transmittance and forward scattering measurements as well as intensity correlation experiments were used to monitor tissue structural and optical properties. As a control, tissue samples of the human sclera were taken. Osmotically active solutions, such as Trazograph, glucose, and polyethylene glycol, were used as chemicals. A characteristic time response of human scleral optical clearing the range 3 to 10 min was determined. The diffusion coefficients describing the permeability of the scleral samples to Trazograph were experimentally estimated; the average value was DT≈(0.9±0.5)×10-5 cm2/s. The results are general and can be used to describe many other fibrous tissues.

Paper Details

Date Published: 1 October 1997
PDF: 17 pages
J. Biomed. Opt. 2(4) doi: 10.1117/12.281502
Published in: Journal of Biomedical Optics Volume 2, Issue 4
Show Author Affiliations
Valery V. Tuchin, Saratov State Univ. (Russia)
Irina L. Maksimova, Institute of Radio Engineering and Electronics (Russia)
Dmitry A. Zimnyakov, Saratov State Univ. (Russia)
Irina L. Kon, Saratov State Medical Univ. (Russia)
Albert H. Mavlyutov, Saratov State Univ. (Russia)
Alexey A. Mishin, Precision Mechanics and Control Institute (Russia)


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