Share Email Print
cover

Journal of Biomedical Optics

Use of near infrared spectroscopy for the clinical monitoring of adult brain
Author(s): Peter J. Kirkpatrick; Piotr Smielewski; Joseph M. K. Lam; Pippa G. Al-Rawi
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

Adult near infrared spectroscopy (NIRS) is a potential method for noninvasively assessing changes in cerebral oxygenation. Unlike neonatal NIRS, access of light to the adult brain requires penetration through thick extracranial tissues, and hence detection of changes in cerebral chromophore concentration can only be achieved by using NIRS in the reflectance mode. This adds variables that are difficult to control. They include the effects of a different intraoptode distance, intersubject anatomical variation, and the influence of a pathological extra- to intracranial collateral blood supply. Although studies showing movements of oxyhemoglobin concentration following specific cerebral stimuli have been published, the separation of changes occurring in the extracranial and intracranial compartments remains a challenge. Experience with NIRS in the three adult clinical scenarios of carotid endarterectomy, head injury, and carbon dioxide stress testing is presented. The influence of extracranial contamination is demonstrated, as are the methods adopted to help control for extracranial blood flow changes. Provisional experience with spatially resolved spectroscopy (SRS) technology is also discussed.

Paper Details

Date Published: 1 October 1996
PDF: 10 pages
J. Biomed. Opt. 1(4) doi: 10.1117/12.252413
Published in: Journal of Biomedical Optics Volume 1, Issue 4
Show Author Affiliations
Peter J. Kirkpatrick, Addenbrookes Hospital (United Kingdom)
Piotr Smielewski, Addenbrookes Hospital (United Kingdom)
Joseph M. K. Lam, Addenbrookes Hospital (United Kingdom)
Pippa G. Al-Rawi, Addenbrookes Hospital (United Kingdom)


© SPIE. Terms of Use
Back to Top