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Journal of Biomedical Optics

Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women
Author(s): Kazunori Suzuki; Yutaka Yamashita; Kazuyoshi Ohta; Masao Kaneko; Masayuki Yoshida; Britton Chance
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Paper Abstract

Previous investigation has proved time-resolved spectroscopy to be applicable to measurement of optical parameters in the human breast. To increase knowledge of these properties in vivo, the optical parameters of healthy breasts were measured using time-resolved reflectance spectroscopy. A time correlated single-photon counting method was used to obtain time-response curves for the breasts of 30 Japanese women. Values of ma (absorption coefficient) and ms8 (transport scattering coefficient) were analyzed by fitting the curves to the diffusion equation. The relationships of optical parameters to age, body mass index (BMI), thickness of the breast, number of pregnancies, and menstrual status were examined. The ma and ms8 ranged from 0.0024 to 0.0078/mm and from 0.63 to 1.08/mm, respectively. The values of ma and ms8 showed a high correlation with age and BMI, respectively. The range of the optical parameters of the healthy breasts was determined. These properties may be strongly influenced by changes in tissue components related to aging, menstrual status, and so on. This optical information will contribute to the investigation of photon migration in the human breast.

Paper Details

Date Published: 1 July 1996
PDF: 5 pages
J. Biomed. Opt. 1(3) doi: 10.1117/12.239902
Published in: Journal of Biomedical Optics Volume 1, Issue 3
Show Author Affiliations
Kazunori Suzuki, Hamamatsu Univ. School of Medicine (Japan)
Yutaka Yamashita, Hamamatsu Photonics KK (Japan)
Kazuyoshi Ohta, Hamamatsu Photonics K.K. (Japan)
Masao Kaneko, Hamamatsu Photonics (Japan)
Masayuki Yoshida, Hamamatsu Univ. School of Medicine (Japan)
Britton Chance, Univ. of Pennsylvania School of Medicine (United States)

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