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Journal of Biomedical Optics

Noncontact determination of thermal diffusivity in biomaterials using infrared imaging radiometry
Author(s): Thomas E. Milner; Dennis M. Goodman; B. Samuel Tanenbaum; Bahman Anvari; J. Stuart Nelson
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Paper Abstract

A noncontact method to determine the thermal diffusivity of biomaterials is derived theoretically and demonstrated experimentally. Assuming that the initial three-dimensional temperature distribution in the biomaterial immediately following pulsed laser irradiation can be separated into lateral and longitudinal factors, a convolution equation is derived that relates a pair of infrared emission images to the lateral thermal point spread function. Pairs of infrared emission images recorded following pulsed laser irradiation are used in combination with a nonlinear least-squares algorithm to determine the lateral thermal point spread function and thus the thermal diffusivity of the biomaterial. Sequences of infrared emission images recorded following pulsed laser irradiation are used to determine thermal diffusivity (0.10360.007 mm2/s) of an in vitro type I hydrated collagen film. Application of the method to in vivo tissues is discussed.

Paper Details

Date Published: 1 January 1996
PDF: 6 pages
J. Biomed. Opt. 1(1) doi: 10.1117/12.227537
Published in: Journal of Biomedical Optics Volume 1, Issue 1
Show Author Affiliations
Thomas E. Milner, Beckman Laser Institute and Medical Clinic (United States)
Dennis M. Goodman, Lawrence Livermore National Lab. (United States)
B. Samuel Tanenbaum, Harvey Mudd College (United States)
Bahman Anvari, Univ. of California/Irvine (United States)
J. Stuart Nelson, Univ. of California/Irvine (United States)

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