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Optical Engineering • Open Access

Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging
Author(s): Liang Li; Siyuan Zhang; Ruizhe Li; Zhiqiang Chen

Paper Abstract

X-ray fluorescence computed tomography (XFCT) was performed on a high-intensity synchrotron radiation source or a pencil beam with a long exposure time due to the low emission and detection efficiency of x-ray fluorescence photons. For the first time, the feasibility and experimental results of a full-field fan-beam XFCT with a photon-counting detector array are presented. This full-field fan-beam XFCT consists of a conventional low-intensity x-ray tube, an energy-sensitive photon-counting detector array, and a tungsten pinhole collimator. A phantom containing gadolinium solution ( K α , 42.74 keV) was scanned for 30 min using a polychromatic x-ray fan beam with a third-generation computed tomography (CT) geometry. After scattering and attenuation corrections, experimental results showed that XFCT had better accuracy and performance than spectral CT. Full-field XFCT is a promising modality for biomedical imaging of exogenous molecular probes containing nanoparticles of high atomic number.

Paper Details

Date Published: 20 April 2017
PDF: 5 pages
Opt. Eng. 56(4) 043106 doi: 10.1117/1.OE.56.4.043106
Published in: Optical Engineering Volume 56, Issue 4
Show Author Affiliations
Liang Li, Tsinghua University (China)
Tsinghua University (China)
Siyuan Zhang, Tsinghua University (China)
Tsinghua University (China)
Ruizhe Li, Tsinghua University (China)
Tsinghua University (China)
Zhiqiang Chen, Tsinghua University (China)
Tsinghua University (China)

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