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Optical Engineering

Video-rate volumetric optical coherence tomography-based microangiography
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Paper Abstract

Video-rate volumetric optical coherence tomography (vOCT) is relatively young in the field of OCT imaging but has great potential in biomedical applications. Due to the recent development of the MHz range swept laser sources, vOCT has started to gain attention in the community. Here, we report the first in vivo video-rate volumetric OCT-based microangiography (vOMAG) system by integrating an 18-kHz resonant microelectromechanical system (MEMS) mirror with a 1.6-MHz FDML swept source operating at ∼1.3  μm wavelength. Because the MEMS scanner can offer an effective B-frame rate of 36 kHz, we are able to engineer vOMAG with a video rate up to 25 Hz. This system was utilized for real-time volumetric in vivo visualization of cerebral microvasculature in mice. Moreover, we monitored the blood perfusion dynamics during stimulation within mouse ear in vivo. We also discussed this system’s limitations. Prospective MEMS-enabled OCT probes with a real-time volumetric functional imaging capability can have a significant impact on endoscopic imaging and image-guided surgery applications.

Paper Details

Date Published: 26 April 2016
PDF: 4 pages
Opt. Eng. 55(4) 040503 doi: 10.1117/1.OE.55.4.040503
Published in: Optical Engineering Volume 55, Issue 4
Show Author Affiliations
Utku Baran, Univ. of Washington (United States)
Wei Wei, Univ. of Washington (United States)
Jingjiang Xu, Univ. of Washington (United States)
Xiaoli Qi, Univ. of Washington (United States)
Wyatt O. Davis, MicroVision, Inc. (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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