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Optical Engineering

Phase measurements of erythrocytes affected by metal ions with quantitative interferometric microscopy
Author(s): Shouyu Wang; Keding Yan; Yanke Shan; Mingfei Xu; Fei Liu; Liang Xue
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Paper Abstract

Erythrocyte morphology is an important factor in disease diagnosis, however, traditional setups as microscopes and cytometers cannot provide enough quantitative information of cellular morphology for in-depth statistics and analysis. In order to capture variations of erythrocytes affected by metal ions, quantitative interferometric microscopy (QIM) is applied to monitor their morphology changes. Combined with phase retrieval and cell recognition, erythrocyte phase images, as well as phase area and volume, can be accurately and automatically obtained. The research proves that QIM is an effective tool in cellular observation and measurement.

Paper Details

Date Published: 30 December 2015
PDF: 8 pages
Opt. Eng. 54(12) 124105 doi: 10.1117/1.OE.54.12.124105
Published in: Optical Engineering Volume 54, Issue 12
Show Author Affiliations
Shouyu Wang, Jiangnan Univ. (China)
Keding Yan, Xi’an Technological Univ. (China)
Yanke Shan, Nanjing Agricultural Univ. (China)
Mingfei Xu, Nanjing Agricultural Univ. (China)
Fei Liu, Nanjing Agricultural Univ. (China)
Liang Xue, Shanghai Univ. of Electric Power (China)

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