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Optical Engineering

Development of silicon-on-insulator-based nanoporous silicon photonic crystals for label-free DNA detection
Author(s): Xiaoyi Lv; Furu Zhong; Zhenhong Jia; Liangliang Chen; Ji Ma; Hongyan Zhang; Zhuangqi Cao; Jun Zhou
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Paper Abstract

We fabricated a one-dimensional nanoporous silicon photonic crystal on a silicon insulator substrate by a cost-effective electrochemical method as an optical biosensor for the detection of DNA hybridization. In the first step, a transfer matrix method was used to calculate the corresponding reflectivity spectrum for the design of nanoporous silicon photonic crystals. Then silicon-on-insulator-based photonic crystals were prepared by a novel simple electrochemical etching. Genes were hybridized inside the porous silicon (PS) pores by aminopropyltriethoxysilane and glutaraldehyde and detected through frequency resolved reflectance measurements. A detection sensitivity of 17.445  nm/μM is demonstrated with good specific detection. The linear response range covers a concentration range of antifreeze protein gene from 0.625 to 10.000 μM. This high responsivity indicates that the silicon-on-insulator-based PS photonic crystal has significant potential for application in biological micro-electro-mechanical-systems technologies.

Paper Details

Date Published: 3 June 2013
PDF: 6 pages
Opt. Eng. 52(6) 064401 doi: 10.1117/1.OE.52.6.064401
Published in: Optical Engineering Volume 52, Issue 6
Show Author Affiliations
Xiaoyi Lv, Xinjiang Univ. (China)
Furu Zhong, Shihezi Univ. (China)
Zhenhong Jia, Xinjiang Univ. (China)
Liangliang Chen, Xinjiang Univ. (China)
Ji Ma, Xinjiang Univ. (China)
Hongyan Zhang, Xinjiang Univ. (China)
Zhuangqi Cao, Shanghai Jiao Tong Univ. (China)
Jun Zhou, Ningbo Univ. (China)

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