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Optical Engineering

True color blood flow imaging using a high-speed laser photography system
Author(s): Chien-Sheng Liu; Cheng-Hsien Lin; Yung-Nien Sun; Chung-Liang Ho; Chung-Chi Hsu
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Paper Abstract

Physiological changes in the retinal vasculature are commonly indicative of such disorders as diabetic retinopathy, glaucoma, and age-related macular degeneration. Thus, various methods have been developed for noninvasive clinical evaluation of ocular hemodynamics. However, to the best of our knowledge, current ophthalmic instruments do not provide a true color blood flow imaging capability. Accordingly, we propose a new method for the true color imaging of blood flow using a high-speed pulsed laser photography system. In the proposed approach, monochromatic images of the blood flow are acquired using a system of three cameras and three color lasers (red, green, and blue). A high-quality true color image of the blood flow is obtained by assembling the monochromatic images by means of image realignment and color calibration processes. The effectiveness of the proposed approach is demonstrated by imaging the flow of mouse blood within a microfluidic channel device. The experimental results confirm the proposed system provides a high-quality true color blood flow imaging capability, and therefore has potential for noninvasive clinical evaluation of ocular hemodynamics.

Paper Details

Date Published: 1 October 2012
PDF: 9 pages
Opt. Eng. 51(10) 103201 doi: 10.1117/1.OE.51.10.103201
Published in: Optical Engineering Volume 51, Issue 10
Show Author Affiliations
Chien-Sheng Liu, National Chung Cheng Univ. (China)
Cheng-Hsien Lin, Chung-Shan Institute of Science and Technology (Taiwan)
Yung-Nien Sun, National Cheng Kung Univ. (Taiwan)
Chung-Liang Ho, National Cheng Kung Univ. (Taiwan)
Chung-Chi Hsu, National Cheng Kung Univ. (Taiwan)

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