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Neurophotonics • Open Access • new

Non-neuronal evoked and spontaneous hemodynamic changes in the anterior temporal region of the human head may lead to misinterpretations of functional near-infrared spectroscopy signals
Author(s): Guilherme Agusto Zimeo Morais; Felix Scholkmann; Joana Bisol Balardin; Rogério Akira Furucho; Renan Costa Vieira de Paula; Claudinei Eduardo Biazoli; João Ricardo Sato

Paper Abstract

Several functional near-infrared spectroscopy (fNIRS) studies report their findings based on changes of a single chromophore, usually concentration changes of oxygenated hemoglobin ([O2Hb]) or deoxygenated hemoglobin (HHb). However, influence of physiological actions may differ depending on which element is considered and the assumption that the chosen measure correlates with the neural response of interest might not hold. By assessing the correlation between [O2Hb] and [HHb] in task-evoked activity as well as resting-state data, we identified a spatial dependency of non-neuronal hemodynamic changes in the anterior temporal region of the human head. Our findings support the importance of reporting and discussing fNIRS outcomes obtained with both chromophores ([O2Hb] and [HHb]), in particular, for studies concerning the anterior temporal region of the human head. This practice should help to achieve a physiologically correct interpretation of the results when no measurements with short-distance channels are available while employing continuous-wave fNIRS systems.

Paper Details

Date Published: 22 August 2017
PDF: 9 pages
5(1) 011002 doi: 10.1117/1.NPh.5.1.011002
Published in: Neurophotonics Volume 5, Issue 1
Show Author Affiliations
Guilherme Agusto Zimeo Morais, NIRx Medical Technologies, LLC (Germany)
Felix Scholkmann, UniversitätsSpital Zürich (Switzerland)
Joana Bisol Balardin, Univ. Federal do ABC (Brazil)
Instituto do Cérebro, Hospital Israelita Albert Einstein (Brazil)
Rogério Akira Furucho, Univ. Federal do ABC (Brazil)
Renan Costa Vieira de Paula, Univ. Federal do ABC (Brazil)
Claudinei Eduardo Biazoli, Univ. Federal do ABC (Brazil)
João Ricardo Sato, Univ. Federal do ABC (Brazil)

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