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Evaluation of evoked responses to pulse-matched high frequency and intermittent theta burst transcranial magnetic stimulation using simultaneous functional near-infrared spectroscopy
Author(s): Adrian Curtin; Junfeng Sun; Hasan Ayaz; ZhenYing Qian; Banu K. Onaral; Jijun Wang; Shanbao Tong
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Paper Abstract

Transcranial magnetic stimulation (TMS) is a noninvasive method used to excite or inhibit cortical activity for experimental, diagnostic, and therapeutic interventions. However, nonmotor regions of the brain targeted in TMS therapies, such as the dorsolateral prefrontal cortex (DLPFC), offer no extrinsic response to stimulation, resulting in a need for a practical method for the evaluation of treatment. We sought to determine the capability of a continuous-wave light emitting diodes (LED)-based functional near-infrared spectroscopy (fNIRS) system to measure evoked cortical hemoglobin changes in the DLPFC during the simultaneous application of TMS to the left-DLPFC under brief stimulation paradigms used in the clinic. Seventeen healthy participants received short TMS trains at F3 in four different stimulation conditions (single pulse, high frequency, intermittent theta burst, and sham) while adjacent fNIRS measurements were recorded. Ten 2-s trains of each stimulation type were delivered with an intertrial interval of 40 s. Results indicated that high-frequency stimulation produces a larger and more evident response than other measured conditions. These findings show that a continuous-wave LED-based fNIRS system can be used to measure TMS-evoked responses and that future TMS applications can benefit from concurrent assessment of localized cortical activation changes.

Paper Details

Date Published: 17 August 2017
PDF: 8 pages
Neurophoton. 4(4) 041405 doi: 10.1117/1.NPh.4.4.041405
Published in: Neurophotonics Volume 4, Issue 4
Show Author Affiliations
Adrian Curtin, Shanghai Jiao Tong Univ. (China)
Drexel Univ. (United States)
Junfeng Sun, Shanghai Jiao Tong Univ. (China)
Hasan Ayaz, Drexel Univ. (United States)
Univ. of Pennsylvania (United States)
Children’s Hospital of Philadelphia, The Division of General Pediatrics, Philadelphia, Pennsylvania (United States)
ZhenYing Qian, Shanghai Jiao Tong Univ. School of Medicine (China)
Banu K. Onaral, Drexel Univ. (United States)
Jijun Wang, Shanghai Jiao Tong Univ. School of Medicine (China)
Shanbao Tong, Shanghai Jiao Tong Univ. (China)

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