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Neurophotonics • Open Access

Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald
Author(s): Chenchen Song; Samuel J. Barnes; Thomas Knöpfel

Paper Abstract

The pioneering work of Amiram Grinvald established voltage-sensitive dye imaging (VSDI) in the mammalian cortex in the 1980s and inspired decades of cortical voltage imaging and the associated technological developments. The recent conception and development of genetically encoded voltage indicators (GEVIs) overcome many of the limitations of classical VSDI, and open experimental approaches that provide accruing support for orchestrated neuronal circuit dynamics of spatially distributed neuronal circuit underlying behaviors. We will review recent achievements using GEVIs to optically monitor the cortical activity in mammalian brains in vivo and provide a perspective for potential future directions.

Paper Details

Date Published: 4 May 2017
PDF: 8 pages
Neurophoton. 4(3) 031214 doi: 10.1117/1.NPh.4.3.031214
Published in: Neurophotonics Volume 4, Issue 3
Show Author Affiliations
Chenchen Song, Imperial College London (United Kingdom)
Samuel J. Barnes, Imperial College London (United Kingdom)
Thomas Knöpfel, Imperial College London (United Kingdom)
Institute of Biomedical Engineering (United Kingdom)


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