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Neurophotonics • Open Access

Review of imaging network activities in developing rodent cerebral cortex in vivo
Author(s): Heiko J. Luhmann

Paper Abstract

The combination of voltage-sensitive dye imaging (VSDI) with multielectrode array (MEA) recordings in the rodent cerebral cortex in vivo allows the simultaneous analysis of large-scale network interactions and electrophysiological single-unit recordings. Using this approach, distinct patterns of spontaneous and sensory-evoked activity can be recorded in the primary somatosensory (S1) and motor cortex (M1) of newborn rats. Already at the day of birth, gamma oscillations and spindle bursts in the barrel cortex synchronize the activity of a local columnar ensemble, thereby generating an early topographic representation of the sensory periphery. During the first postnatal week, both cortical activity patterns undergo developmental changes in their spatiotemporal properties and spread into neighboring cortical columns. Simultaneous VSDI and MEA recordings in S1 and M1 demonstrate that the immature motor cortex receives information from the somatosensory system and that M1 may trigger movements of the periphery, which subsequently evoke gamma oscillations and spindle bursts in S1. These early activity patterns not only play an important role in the development of the cortical columnar architecture, they also control the ratio of surviving versus dying neurons in an activity-dependent manner, making these processes most vulnerable to pathophysiological disturbances during early developmental stages.

Paper Details

Date Published: 23 November 2016
PDF: 8 pages
Neurophoton. 4(3) 031202 doi: 10.1117/1.NPh.4.3.031202
Published in: Neurophotonics Volume 4, Issue 3
Show Author Affiliations
Heiko J. Luhmann, University Medical Center of the Johannes Gutenberg University Mainz (Germany)


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