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Neurophotonics • Open Access

Review of the potential of optical technologies for cancer diagnosis in neurosurgery: a step toward intraoperative neurophotonics

Paper Abstract

Advances in image-guided therapy enable physicians to obtain real-time information on neurological disorders such as brain tumors to improve resection accuracy. Image guidance data include the location, size, shape, type, and extent of tumors. Recent technological advances in neurophotonic engineering have enabled the development of techniques for minimally invasive neurosurgery. Incorporation of these methods in intraoperative imaging decreases surgical procedure time and allows neurosurgeons to find remaining or hidden tumor or epileptic lesions. This facilitates more complete resection and improved topology information for postsurgical therapy (i.e., radiation). We review the clinical application of recent advances in neurophotonic technologies including Raman spectroscopy, thermal imaging, optical coherence tomography, and fluorescence spectroscopy, highlighting the importance of these technologies in live intraoperative tissue mapping during neurosurgery. While these technologies need further validation in larger clinical trials, they show remarkable promise in their ability to help surgeons to better visualize the areas of abnormality and enable safe and successful removal of malignancies.

Paper Details

Date Published: 26 December 2016
PDF: 10 pages
4(1) 011010 doi: 10.1117/1.NPh.4.1.011010
Published in: Neurophotonics Volume 4, Issue 1
Show Author Affiliations
Fartash Vasefi, Spectral Molecular Imaging, Inc. (United States)
Brain Mapping Foundation (United States)
Society for Brain Mapping and Therapeutics (United States)
Nicholas MacKinnon, Spectral Molecular Imaging, Inc. (United States)
Daniel L. Farkas, Spectral Molecular Imaging, Inc. (United States)
Univ. of Southern California (United States)
Babak Kateb, Brain Mapping Foundation (United States)
Society for Brain Mapping and Therapeutics (United States)
California Neurosurgical Institute (United States)


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