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Neurophotonics

Spatial landscape of oxygen in and around microvasculature during epileptic events
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Paper Abstract

Measuring changes in cerebral oxygen in tissue microdomains during epilepsy is important to identify hypoxic potential. Here, using a custom-built two-photon microscopy system, we present microscopic measurements of oxygen partial pressure ( PO 2 ) in cortical microvessels and tissue of anesthetized mice during 4-aminopyridine (4-AP)-induced epileptic seizures. Investigating epileptic events, we characterized the distribution of the “initial dip” in PO 2 in arterioles, venules, and tissue near the 4-AP injection site. Our results reveal a correlation between the percent change in PO 2 during the “initial dip” and the diameter of nearest arterioles and venules.

Paper Details

Date Published: 11 March 2017
PDF: 4 pages
Neurophoton. 4(1) 010501 doi: 10.1117/1.NPh.4.1.010501
Published in: Neurophotonics Volume 4, Issue 1
Show Author Affiliations
Cong Zhang, Ecole Polytechnique de Montréal (Canada)
Institut de Cardiologie de Montréal (Canada)
Mohammad Moeini, Ecole Polytechnique de Montréal (Canada)
Institut de Cardiologie de Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)
Institut de Cardiologie de Montréal (Canada)


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