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Neurophotonics • Open Access

Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests

Paper Abstract

We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders. The SiPM is inserted into a transparent and insulating resin to avoid the direct contact of the scalp with the 100-V bias voltage. The probe was integrated in an instrument for TD fNIRS spectroscopy. The system was characterized on tissue phantoms in terms of temporal resolution, responsivity, linearity, and capability to detect deep absorption changes. Preliminary in vivo tests on adult volunteers were performed to monitor hemodynamic changes in the arm during a cuff occlusion and in the brain cortex during a motor task.

Paper Details

Date Published: 12 October 2016
PDF: 9 pages
Neurophoton. 3(4) 045004 doi: 10.1117/1.NPh.3.4.045004
Published in: Neurophotonics Volume 3, Issue 4
Show Author Affiliations
Rebecca Re, Politecnico di Milano (Italy)
Edoardo Martinenghi, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)

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