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Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging
Author(s): Julien Pichette; Audrey Laurence; Leticia Angulo; Frederic Lesage; Alain Bouthillier; Dang Khoa Nguyen; Frédéric Leblond
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Paper Abstract

Using light, we are able to visualize the hemodynamic behavior of the brain to better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of tissue using endogenous chromophores necessitates spectroscopic detection to ensure molecular specificity as well as sufficiently high imaging speed and signal-to-noise ratio, to allow dynamic physiological changes to be captured, isolated, and used as surrogate of pathophysiological processes. An optical imaging system is introduced using a 16-bands on-chip hyperspectral camera. Using this system, we show that up to three dyes can be imaged and quantified in a tissue phantom at video-rate through the optics of a surgical microscope. In vivo human patient data are presented demonstrating brain hemodynamic response can be measured intraoperatively with molecular specificity at high speed.

Paper Details

Date Published: 12 October 2016
PDF: 9 pages
3(4) 045003 doi: 10.1117/1.NPh.3.4.045003
Published in: Neurophotonics Volume 3, Issue 4
Show Author Affiliations
Julien Pichette, Ecole Polytechnique de Montréal (Canada)
Audrey Laurence, Ecole Polytechnique de Montréal (Canada)
Leticia Angulo, Ecole Polytechnique de Montréal (Canada)
Frederic Lesage, Ecole Polytechnique de Montréal (Canada)
Alain Bouthillier, Univ. de Montréal (Canada)
Dang Khoa Nguyen, Ctr. Hospitalier de l'Univ. de Montréal (Canada)
Frédéric Leblond, Ecole Polytechnique de Montréal (Canada)
Ctr. Hospitalier de l’Univ. de Montréal (Canada)

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