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Neurophotonics • Open Access

Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease
Author(s): Clemens F. Kaminski; Gabriele S. Kaminski Schierle

Paper Abstract

The misfolding and self-assembly of intrinsically disordered proteins into insoluble amyloid structures are central to many neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Optical imaging of this self-assembly process <italic<in vitro</italic< and in cells is revolutionizing our understanding of the molecular mechanisms behind these devastating conditions. In contrast to conventional biophysical methods, optical imaging and, in particular, optical superresolution imaging, permits the dynamic investigation of the molecular self-assembly process <italic<in vitro</italic< and in cells, at molecular-level resolution. In this article, current state-of-the-art imaging methods are reviewed and discussed in the context of research into neurodegeneration.

Paper Details

Date Published: 29 June 2016
PDF: 9 pages
3(4) 041807 doi: 10.1117/1.NPh.3.4.041807
Published in: Neurophotonics Volume 3, Issue 4
Show Author Affiliations
Clemens F. Kaminski, Univ. of Cambridge (United Kingdom)
Gabriele S. Kaminski Schierle, Univ. of Cambridge (United Kingdom)

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