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Neurophotonics • Open Access

Proposal of auxiliary diagnosis index for autism spectrum disorder using near-infrared spectroscopy
Author(s): Kazuki Yanagisawa; Nozomi Nakamura; Hitoshi Tsunashima; Naoko Narita

Paper Abstract

Lack of a diagnostic index is a problem that needs to be overcome in the diagnosis of autism spectrum disorder (ASD), because this problem prevents an objective assessment based on biomarkers. This paper describes the development of a diagnostic index for ASD using near-infrared spectroscopy (NIRS). We investigated continuous prefrontal hemodynamic changes depending on reciprocal disposition of working memory and nonworking memory tasks using two-channel NIRS. NIRS signals in the prefrontal cortex were compared between high-functioning ASD subjects (n=11) and typically developed (TD) subjects (n=21). The brain activities of the TD subjects were related to experimental design. These results were not confirmed in brain activities of ASD subjects, although the task performance rate was almost equivalent. The brain activities of TD subjects and ASD subjects were evaluated using a weighted separability (WS) index obtained from the feature phase of oxy-hemoglobin and its differential value. Calculation of the t-test (TD subject versus ASD subject) confirmed that WS was significant. This result showed that the proposed index was useful for evaluation of the brain activity of ASD subjects.

Paper Details

Date Published: 9 June 2016
PDF: 8 pages
Neurophoton. 3(3) 031413 doi: 10.1117/1.NPh.3.3.031413
Published in: Neurophotonics Volume 3, Issue 3
Show Author Affiliations
Kazuki Yanagisawa, College of Industrial Technology, Nihon Univ. (Japan)
Nozomi Nakamura, College of Industrial Technology, Nihon Univ. (Japan)
Hitoshi Tsunashima, College of Industrial Technology, Nihon Univ. (Japan)
Naoko Narita, Bunkyo Univ. (Japan)

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