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Neurophotonics

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy
Author(s): Maria Chalia; Chuen Wai Lee; Laura A. Dempsey; Andrea D. Edwards; Harsimrat Singh; Andrew W. Michell; Nicholas L. Everdell; Reuben W. Hill; Jeremy C. Hebden; Topun Austin; Robert J. Cooper
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Paper Abstract

Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.

Paper Details

Date Published: 2 May 2016
PDF: 10 pages
3(3) 031408 doi: 10.1117/1.NPh.3.3.031408
Published in: Neurophotonics Volume 3, Issue 3
Show Author Affiliations
Maria Chalia, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Chuen Wai Lee, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Laura A. Dempsey, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Univ. College London (United Kingdom)
Andrea D. Edwards, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Harsimrat Singh, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Univ. College London (United Kingdom)
Andrew W. Michell, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Nicholas L. Everdell, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Univ. College London (United Kingdom)
Reuben W. Hill, Univ. College London (United Kingdom)
Jeremy C. Hebden, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Univ. College London (United Kingdom)
Topun Austin, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Robert J. Cooper, Cambridge Univ. Hospitals NHS Foundation Trust (United Kingdom)
Univ. College London (United Kingdom)


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