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Neurophotonics • Open Access

Near-infrared measurements of brain oxygenation in stroke
Author(s): François Moreau; Runze Yang; Vivek Nambiar; Andrew M. Demchuk; Jeff F. Dunn

Paper Abstract

We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and StO2 in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. StO2 values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced StO2 on the stroke side compared to the contralateral side. The evolution of tHb and StO2 at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.

Paper Details

Date Published: 11 February 2016
PDF: 8 pages
Neurophoton. 3(3) 031403 doi: 10.1117/1.NPh.3.3.031403
Published in: Neurophotonics Volume 3, Issue 3
Show Author Affiliations
François Moreau, Univ. de Sherbrooke (Canada)
Calgary Stroke Program (Canada)
Runze Yang, Univ. of Calgary (Canada)
Vivek Nambiar, Foothills Medical Ctr. (Canada)
Amrita Institute Medical Sciences (India)
Andrew M. Demchuk, Foothills Medical Ctr. (Canada)
Univ. of Calgary (Canada)
Jeff F. Dunn, Univ. of Calgary (Canada)

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