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Neurophotonics • Open Access

Multichannel continuous electroencephalography-functional near-infrared spectroscopy recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review
Author(s): Ke Peng; Philippe Pouliot; Frédéric Lesage; Dang Khoa Nguyen

Paper Abstract

Functional near-infrared spectroscopy (fNIRS) has emerged as a promising neuroimaging technique as it allows noninvasive and long-term monitoring of cortical hemodynamics. Recent work by our group and others has revealed the potential of fNIRS, combined with electroencephalography (EEG), in the context of human epilepsy. Hemodynamic brain responses attributed to epileptic events, such as seizures and interictal epileptiform discharges (IEDs), are routinely observed with a good degree of statistical significance and in concordance with clinical presentation. Recording done with over 100 channels allows sufficiently large coverage of the epileptic focus and other areas. Three types of seizures have been documented: frontal lobe seizures, temporal lobe seizures, and posterior seizures. Increased oxygenation was observed in the epileptic focus in most cases, while rapid but similar hemodynamic variations were identified in the contralateral homologous region. While investigating IEDs, it was shown that their hemodynamic effect is observable with fNIRS, that their response is associated with significant (inhibitive) nonlinearities, and that the sensitivity and specificity of fNIRS to localize the epileptic focus can be estimated in a sample of 40 patients. This paper first reviews recent EEG-fNIRS developments in epilepsy research and then describes applications to the study of focal seizures and IEDs.

Paper Details

Date Published: 11 February 2016
PDF: 12 pages
Neurophoton. 3(3) 031402 doi: 10.1117/1.NPh.3.3.031402
Published in: Neurophotonics Volume 3, Issue 3
Show Author Affiliations
Ke Peng, Ecole Polytechnique de Montréal (Canada)
Philippe Pouliot, Ecole Polytechnique de Montréal (Canada)
Institut de Cardiologie de Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)
Institut de Cardiologie de Montréal (Canada)
Dang Khoa Nguyen, Ctr. Hospitalier de l'Univ. de Montréal (Canada)

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