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Neurophotonics • Open Access

Review of optical coherence tomography based angiography in neuroscience
Author(s): Utku Baran; Ruikang K. Wang

Paper Abstract

The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution (∼10  μm) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent developments of OCT-based imaging techniques for neuroscience applications in rodents. We summarize today’s technological alternatives for OCT-based angiography for neuroscience and provide a discussion of challenges and opportunities. Moreover, a summary of OCT angiography studies for stroke, traumatic brain injury, and subarachnoid hemorrhage cases on rodents is provided.

Paper Details

Date Published: 20 January 2016
PDF: 12 pages
Neurophoton. 3(1) 010902 doi: 10.1117/1.NPh.3.1.010902
Published in: Neurophotonics Volume 3, Issue 1
Show Author Affiliations
Utku Baran, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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