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Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping
Author(s): Lia Maria Hocke; Kenroy Cayetano; Yunjie Tong; Blaise deB. Frederick
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Paper Abstract

Functional near-infrared spectroscopy (fNIRS) is an increasingly important noninvasive method in neuroscience due to its high temporal resolution and ability to independently measure oxy- and deoxy-hemoglobin. However, the relatively low spatial resolution of fNIRS makes it difficult to relate this signal to underlying anatomy. Simultaneous functional magnetic resonance imaging (fMRI) can complement fNIRS with superior spatial resolution and the ability to image the entire brain, providing additional information to improve fNIRS localization. However, current simultaneous fMRI/fNIRS acquisition methods are not optimal, due to the poor physical compatibility of existing MR coils and fNIRS optodes. Here, we present a technique to manufacture a true multimodal fMRI/fNIRS probe in which both modalities can be used with maximal sensitivity. To achieve this, we designed custom MR coils with integral fNIRS optodes using three-dimensional printing. This multimodal probe can be used to optimize spatial (1.2×1.2×1.8  mm) and temporal resolution (2.5 Hz) of fMRI, and it provides maximal MRI sensitivity, while allowing for high flexibility in the location and density of fNIRS optodes within the area of interest. Phantom and human data are shown to confirm the improvement in sensitivity in both modalities. This probe shows promise for addressing fundamental questions of the relation of fNIRS to physiology.

Paper Details

Date Published: 10 December 2015
PDF: 10 pages
2(4) 045004 doi: 10.1117/1.NPh.2.4.045004
Published in: Neurophotonics Volume 2, Issue 4
Show Author Affiliations
Lia Maria Hocke, McLean Hospital (United States)
Tufts Univ. (United States)
Kenroy Cayetano, McLean Hospital (United States)
Harvard Medical School (United States)
Yunjie Tong, McLean Hospital (United States)
Harvard Medical School (United States)
Blaise deB. Frederick, McLean Hospital (United States)
Harvard Medical School (United States)

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