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Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
Author(s): Wesley B. Baker; Ashwin B. Parthasarathy; Tiffany S. Ko; David R. Busch; Kenneth Abramson; Shih-Yu Tzeng; Rickson C. Mesquita; Turgut Durduran; Joel H. Greenberg; David K. Kung; Arjun G. Yodh
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Paper Abstract

We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without <italic<a priori</italic< anatomical information. We demonstrate the algorithm’s ability to isolate cerebral blood flow during a finger-tapping task and during graded scalp ischemia in healthy adults. Finally, we adapt the pressure modulation algorithm to ameliorate extracerebral contamination in monitoring of cerebral blood oxygenation and blood volume by near-infrared spectroscopy.

Paper Details

Date Published: 4 August 2015
PDF: 20 pages
2(3) 035004 doi: 10.1117/1.NPh.2.3.035004
Published in: Neurophotonics Volume 2, Issue 3
Show Author Affiliations
Wesley B. Baker, Univ. of Pennsylvania (United States)
Ashwin B. Parthasarathy, Univ. of Pennsylvania (United States)
Tiffany S. Ko, Univ. of Pennsylvania (United States)
David R. Busch, Univ. of Pennsylvania (United States)
The Children's Hospital of Philadelphia (United States)
Kenneth Abramson, Univ. of Pennsylvania (United States)
Shih-Yu Tzeng, Univ. of Pennsylvania (United States)
National Cheng Kung Univ. (Taiwan)
Rickson C. Mesquita, Univ. Estadual de Campinas (Brazil)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Joel H. Greenberg, The Univ. of Pennsylvania Health System (United States)
David K. Kung, Hospital of the Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)

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