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Neurophotonics • Open Access

Evaluation of rigid registration methods for whole head imaging in diffuse optical tomography
Author(s): Xue Wu; Adam T. Eggebrecht; Silvina L. Ferradal; Joseph P. Culver; Hamid Dehghani

Paper Abstract

Functional brain imaging has become an important neuroimaging technique for the study of brain organization and development. Compared to other imaging techniques, diffuse optical tomography (DOT) is a portable and low-cost technique that can be applied to infants and hospitalized patients using an atlas-based light model. For DOT imaging, the accuracy of the forward model has a direct effect on the resulting recovered brain function within a field of view and so the accuracy of the spatially normalized atlas-based forward models must be evaluated. Herein, the accuracy of atlas-based DOT is evaluated on models that are spatially normalized via a number of different rigid registration methods on 24 subjects. A multileveled approach is developed to evaluate the correlation of the geometrical and sensitivity accuracies across the full field of view as well as within specific functional subregions. Results demonstrate that different registration methods are optimal for recovery of different sets of functional brain regions. However, the “nearest point to point” registration method, based on the EEG 19 landmark system, is shown to be the most appropriate registration method for image quality throughout the field of view of the high-density cap that covers the whole of the optically accessible cortex.

Paper Details

Date Published: 21 July 2015
PDF: 13 pages
2(3) 035002 doi: 10.1117/1.NPh.2.3.035002
Published in: Neurophotonics Volume 2, Issue 3
Show Author Affiliations
Xue Wu, The Univ. of Birmingham (United Kingdom)
Adam T. Eggebrecht, Washington Univ. School of Medicine in St. Louis (United States)
Silvina L. Ferradal, Fetal-Neonatal Neuroimaging and Developmental Science Ctr. (United States)
Joseph P. Culver, Washington Univ. School of Medicine in St. Louis (United States)
Washington Univ. (United States)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)

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