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Optical coherence tomography for cross-sectional imaging of neural activity
Author(s): Yi-Jou Yeh; Adam J. Black; David Landowne; Taner Akkin
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Paper Abstract

We report a functional optical coherence tomography cross-sectional scanner to detect neural activity using unmyelinated nerves dissected from squid. The nerves, unstained or stained with a voltage-sensitive dye, were imaged in a nerve chamber. Transient phase changes from backscattered light were detected during action potential propagation. The results show that the scanner can provide high spatiotemporal resolution cross-sectional images of neural activity (15  μs/A-line; 0.25  ms/B-scan; ∼8.5×5.5  μm2 in xz). The advantage of this method compared to monitoring a single depth profile z is a dramatic increase in the number of available sites that can be measured in two spatial dimensions xz with lateral scanning; therefore, the study demonstrates that two-dimensional monitoring of small-scale functional activity would also be feasible.

Paper Details

Date Published: 21 July 2015
PDF: 9 pages
Neurophoton. 2(3) 035001 doi: 10.1117/1.NPh.2.3.035001
Published in: Neurophotonics Volume 2, Issue 3
Show Author Affiliations
Yi-Jou Yeh, Univ. of Minnesota, Twin Cities (United States)
Adam J. Black, Univ. of Minnesota, Twin Cities (United States)
David Landowne, Univ. of Miami (United States)
Taner Akkin, Univ. of Minnesota, Twin Cities (United States)

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