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Neurophotonics • Open Access

Evolution of optogenetic microdevices
Author(s): Rajas Prakash Kale; Abbas Zahedi Kouzani; Ken Walder; Michael Berk; Susannah J. Tye

Paper Abstract

Implementation of optogenetic techniques is a recent addition to the neuroscientists’ preclinical research arsenal, helping to expose the intricate connectivity of the brain and allowing for on-demand direct modulation of specific neural pathways. Developing an optogenetic system requires thorough investigation of the optogenetic technique and of previously fabricated devices, which this review accommodates. Many experiments utilize bench-top systems that are bulky, expensive, and necessitate tethering to the animal. However, these bench-top systems can make use of power-demanding technologies, such as concurrent electrical recording. Newer portable microdevices and implantable systems carried by freely moving animals are being fabricated that take advantage of wireless energy harvesting to power a system and allow for natural movements that are vital for behavioral testing and analysis. An investigation of the evolution of tethered, portable, and implantable optogenetic microdevices is presented, and an analysis of benefits and detriments of each system, including optical power output, device dimensions, electrode width, and weight is given. Opsins, light sources, and optical fiber coupling are also discussed to optimize device parameters and maximize efficiency from the light source to the fiber, respectively. These attributes are important considerations when designing and developing improved optogenetic microdevices.

Paper Details

Date Published: 25 June 2015
PDF: 11 pages
Neurophoton. 2(3) 031206 doi: 10.1117/1.NPh.2.3.031206
Published in: Neurophotonics Volume 2, Issue 3
Show Author Affiliations
Rajas Prakash Kale, Deakin Univ. (Australia)
Mayo Clinic (United States)
Abbas Zahedi Kouzani, Deakin Univ. (Australia)
Ken Walder, Deakin Univ. (Australia)
Michael Berk, Deakin Univ. (Australia)
Orygen Youth Health (Australia)
The Univ. of Melbourne (Australia)
Susannah J. Tye, Mayo Clinic (United States)

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