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Neurophotonics • Open Access

Optrodes for combined optogenetics and electrophysiology in live animals

Paper Abstract

Optical tissue properties limit visible light depth penetration in tissue. Because of this, the recent development of optogenetic tools was quickly followed by the development of light delivery devices for <italic<in vivo</italic< optogenetics applications. We summarize the efforts made in the last decade to design neural probes that combine conventional electrophysiological recordings and optical channel(s) for optogenetic activation, often referred to as optodes or optrodes. Several aspects including challenges for light delivery in living brain tissue, the combination of light delivery with electrophysiological recordings, probe designs, multimodality, wireless implantable system, and practical considerations guiding the choice of configuration depending on the questions one seeks to address are presented.

Paper Details

Date Published: 2 July 2015
PDF: 14 pages
2(3) 031205 doi: 10.1117/1.NPh.2.3.031205
Published in: Neurophotonics Volume 2, Issue 3
Show Author Affiliations
Suzie Dufour, Toronto Western Research Institute (Canada)
Univ. of Toronto (Canada)
Yves De Koninck, Institut Univ. en Santé Mentale de Québec (Canada)
Univ. Laval (Canada)

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