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Neurophotonics • Open Access

Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy
Author(s): Masako Nagashima; Yukifumi Monden; Ippeita Dan; Haruka Dan; Tsutomu Mizutani; Daisuke Tsuzuki; Yasushi Kyutoku; Yuji Gunji; Daisuke Hirano; Takamichi Taniguchi; Hideo Shimoizumi; Mariko Y. Momoi; Takanori Yamagata; Eiju Watanabe

Paper Abstract

The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

Paper Details

Date Published: 1 October 2014
PDF: 14 pages
1(2) 025007 doi: 10.1117/1.NPh.1.2.025007
Published in: Neurophotonics Volume 1, Issue 2
Show Author Affiliations
Masako Nagashima, Jichi Medical Univ. (Japan)
Yukifumi Monden, Jichi Medical Univ. (Japan)
Ippeita Dan, Jichi Medical Univ. (Japan)
Chuo Univ. (Japan)
Haruka Dan, Jichi Medical Univ. (Japan)
Tsutomu Mizutani, Jichi Medical Univ. (Japan)
Daisuke Tsuzuki, Chuo Univ. (Japan)
Yasushi Kyutoku, Chuo Univ. (Japan)
Yuji Gunji, Jichi Medical Univ. (Japan)
International Univ. of Health and Welfare (Japan)
Daisuke Hirano, International Univ. of Health and Welfare (Japan)
Takamichi Taniguchi, International Univ. of Health and Welfare (Japan)
Hideo Shimoizumi, International Univ. of Health and Welfare (Japan)
Mariko Y. Momoi, International Univ. of Health and Welfare (Japan)
Takanori Yamagata, Jichi Medical Univ. (Japan)
Eiju Watanabe, Jichi Medical Univ. (Japan)


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