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Neurophotonics • Open Access

Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography
Author(s): Carissa L. Rodriguez; Jenny I. Szu; Melissa M. Eberle; Yan Wang; Mike S. Hsu; Devin K. Binder; B. Hyle Park

Paper Abstract

Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema <italic<in vivo</italic<. Three-dimensional imaging of an <italic<in vivo</italic< water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was calculated and cerebral blood flow was analyzed using Doppler OCT techniques. We found that the average attenuation coefficient in the cerebral cortex decreased over time as edema progressed. The initial decrease began within minutes of inducing cerebral edema and a maximum decrease of 8% was observed by the end of the experiment. Additionally, cerebral blood flow slowed during late-stage edema. Analysis of local regions revealed the same trend at various locations in the brain, consistent with the global nature of the cerebral edema model used in this study. These results demonstrate that OCT is capable of detecting <italic<in vivo</italic< optical changes occurring due to cerebral edema and highlights the potential of OCT for precise spatiotemporal detection of cerebral edema.

Paper Details

Date Published: 2 September 2014
PDF: 7 pages
1(2) 025004 doi: 10.1117/1.NPh.1.2.025004
Published in: Neurophotonics Volume 1, Issue 2
Show Author Affiliations
Carissa L. Rodriguez, Univ. of California, Riverside (United States)
Jenny I. Szu, Univ. of California, Riverside (United States)
Melissa M. Eberle, Univ. of California, Riverside (United States)
Yan Wang, Massachusetts General Hospital (United States)
Harvard Medical School (United Kingdom)
Mike S. Hsu, Univ. of California, Riverside (United States)
Umbrella Neurotechnologies (United States)
Devin K. Binder, Univ. of California, Riverside (United States)
Umbrella Neurotechnologies (United States)
B. Hyle Park, Univ. of California, Riverside (United States)

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