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Neurophotonics • Open Access

Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders
Author(s): Pierre Marquet; Christian Depeursinge; Pierre J. Magistretti

Paper Abstract

Quantitative phase microscopy (QPM) has recently emerged as a new powerful quantitative imaging technique well suited to noninvasively explore a transparent specimen with a nanometric axial sensitivity. In this review, we expose the recent developments of quantitative phase-digital holographic microscopy (QP-DHM). Quantitative phase-digital holographic microscopy (QP-DHM) represents an important and efficient quantitative phase method to explore cell structure and dynamics. In a second part, the most relevant QPM applications in the field of cell biology are summarized. A particular emphasis is placed on the original biological information, which can be derived from the quantitative phase signal. In a third part, recent applications obtained, with QP-DHM in the field of cellular neuroscience, namely the possibility to optically resolve neuronal network activity and spine dynamics, are presented. Furthermore, potential applications of QPM related to psychiatry through the identification of new and original cell biomarkers that, when combined with a range of other biomarkers, could significantly contribute to the determination of high risk developmental trajectories for psychiatric disorders, are discussed.

Paper Details

Date Published: 22 September 2014
PDF: 15 pages
1(2) 020901 doi: 10.1117/1.NPh.1.2.020901
Published in: Neurophotonics Volume 1, Issue 2
Show Author Affiliations
Pierre Marquet, Ctr. Hospitalier Univ. Vaudois (Switzerland)
Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christian Depeursinge, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
King Abdullah Univ. of Science and Technology (Kingdom of Saudi Arabia)
Pierre J. Magistretti, Ctr. Hospitalier Univ. Vaudois (Switzerland)
Ecole Polytechnique Fédérale de Lausanne (Switzerland)
King Abdullah Univ. of Science and Technology (Saudi Arabia)


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