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Neurophotonics • Open Access

Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy
Author(s): Masako Nagashima; Yukifumi Monden; Ippeita Dan; Haruka Dan; Daisuke Tsuzuki; Tsutomu Mizutani; Yasushi Kyutoku; Yuji Gunji; Mariko Y. Momoi; Eiju Watanabe; Takanori Yamagata

Paper Abstract

The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

Paper Details

Date Published: 28 May 2014
PDF: 15 pages
Neurophoton. 1(1) 015001 doi: 10.1117/1.NPh.1.1.015001
Published in: Neurophotonics Volume 1, Issue 1
Show Author Affiliations
Masako Nagashima, Jichi Medical Univ. (Japan)
Yukifumi Monden, Jichi Medical Univ. (Japan)
Ippeita Dan, Jichi Medical Univ. (Japan)
Chuo Univ. (Japan)
Haruka Dan, Jichi Medical Univ. (Japan)
Daisuke Tsuzuki, Chuo Univ. (Japan)
Tsutomu Mizutani, Jichi Medical Univ. (Japan)
Yasushi Kyutoku, Chuo Univ. (Japan)
Yuji Gunji, Jichi Medical Univ. (Japan)
International Univ. of Health and Welfare (Japan)
Mariko Y. Momoi, International Univ. of Health and Welfare (Japan)
Eiju Watanabe, Jichi Medical Univ. (Japan)
Takanori Yamagata, Jichi Medical Univ. (Japan)

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