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Journal of Nanophotonics

Nanotopography of collagen thin films in correlation with fibroblast response
Author(s): Andreas Stylianou; Dido M. Yova; Eleni Alexandratou
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Paper Abstract

Collagen thin films consisting of randomly oriented and oriented collagen fibrils/fibers are fabricated by hydrodynamic flow and spin coating, and then they are characterized by atomic force microscopy (AFM). Fibroblasts are cultured on these films in order to correlate their morphology and alignment, which are assessed with fluorescence and AFM imaging with different film characteristics. The results showed that the formed films could be used as substrates for culturing cells. Furthermore, cells reacted to film nanocharacteristics and especially to the orientation of fibrils/fibers. The investigation of the influence that the substrate nanotopography has on cells will help to elucidate the mechanisms of cell–biomaterial interactions, and will enable the design of intelligent coatings for implants and tissue engineering purposes.

Paper Details

Date Published: 25 June 2013
PDF: 16 pages
J. Nanophoton. 7(1) 073590 doi: 10.1117/1.JNP.7.073590
Published in: Journal of Nanophotonics Volume 7, Issue 1
Show Author Affiliations
Andreas Stylianou, National Technical Univ. of Athens (Greece)
Dido M. Yova, National Technical Univ. of Athens (Greece)
Eleni Alexandratou, National Technical Univ. of Athens (Greece)


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