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Journal of Nanophotonics • Open Access

Review of a viral peptide nanosystem for intracellular delivery
Author(s): Annarita Falanga; Rossella Tarallo; Emilia Galdiero; Marco Cantisani; Massimiliano Galdiero; Stefania Galdiero

Paper Abstract

The internalization of bioactive molecules is one of the most critical problems to overcome in theranostics. In order to improve pharmacokinetic and pharmacodynamic properties, synthetic transporters are widely investigated. A new nanotechnological transporter, gH625, is based on a viral peptide sequence derived from the herpes simplex virus type 1 glycoprotein H (gH) that has proved to be a useful delivery vehicle, due to its intrinsic properties of inducing membrane perturbation. The peptide functionalization with several kinds of nanoparticles like quantum dots, dendrimers, and liposomes could be of particular interest in biomedical applications to improve drug release within cells, to increase site-specific action, and eventually to reduce related cytotoxicity.

Paper Details

Date Published: 16 January 2013
PDF: 12 pages
J. Nanophoton. 7(1) 071599 doi: 10.1117/1.JNP.7.071599
Published in: Journal of Nanophotonics Volume 7, Issue 1
Show Author Affiliations
Annarita Falanga, Univ. degli Studi di Napoli Federico II (Italy)
Rossella Tarallo, Univ. degli Studi di Napoli Federico II (Italy)
Emilia Galdiero, Univ. degli Studi di Napoli Federico II (Italy)
Marco Cantisani, Univ. degli Studi di Napoli Federico II (Italy)
Massimiliano Galdiero, Univ. degli Studi di Napoli Federico II (Italy)
Stefania Galdiero, Univ. degli Studi di Napoli Federico II (Italy)


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