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Journal of Nanophotonics

Development of high-sensitive, reproducible colloidal surface-enhanced Raman spectroscopy active substrate using silver nanocubes for potential biosensing applications
Author(s): Kudilatt Hasna; Kiran Lakshmi; Madambi Kunjukuttan Ezhuthachan Jayaraj; Kumaran Rajeev Kumar; Murukeshan Vadakke Matham
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Paper Abstract

Surface-enhanced Raman spectroscopy (SERS) has emerged as one of the thrust research areas that could find potential applications in bio and chemical sensing. We developed colloidal SERS active substrate with excellent sensitivity and high reproducibility using silver nanocube (AgNC) synthesized via the solvothermal method. Finite-difference time-domain simulation was carried out in detail to visualize dipole generation in the nanocube during localized surface plasmon resonance and to locate the respective hot spots in AgNC responsible for the huge Raman enhancement. The prediction is verified by the SERS analysis of the synthesized nanocubes using Rhodamine 6G molecule. An excellent sensitivity with a detection limit of 10−17  M and a very high enhancement factor of 1.2×108 confirms the “hot spots” in the nanocube. SERS activity is also carried out for crystal violet and for food adulterant Sudan I molecule. Finally, label-free DNA detection is performed to demonstrate the versatility of SERS as a potential biosensor.

Paper Details

Date Published: 23 May 2016
PDF: 9 pages
J. Nanophoton. 10(2) 026020 doi: 10.1117/1.JNP.10.026020
Published in: Journal of Nanophotonics Volume 10, Issue 2
Show Author Affiliations
Kudilatt Hasna, Cochin Univ. of Science & Technology (India)
Kiran Lakshmi, Cochin Univ. of Science & Technology (India)
Madambi Kunjukuttan Ezhuthachan Jayaraj, Cochin Univ. of Science & Technology (India)
Kumaran Rajeev Kumar, Cochin Univ. of Science & Technology (India)
Murukeshan Vadakke Matham, Nanyang Technological Univ. (Singapore)

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