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Journal of Medical Imaging • Open Access

Preoperative measurement of cutaneous melanoma and nevi thickness with photoacoustic imaging
Author(s): Aedán Breathnach; Elizabeth Concannon; Jemima J. Dorairaj; Shazrinizam Shaharan; James McGrath; Jithin Jose; Jack L. Kelly; Martin J. Leahy

Paper Abstract

Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented cutaneous lesions suspicious for melanoma to test the feasibility of a handheld linear-array photoacoustic probe in imaging lesion architecture and measuring tumor depth. The probe was assessed in terms of measurement accuracy, image quality, and ease of application. Photoacoustic scans included single wavelength, spectral unmixing, and three-dimensional (3-D) scans. The photoacoustically measured lesion thickness gave a high correlation with the histological thickness measured from resected surgical samples (r=0.99, P<0.001 for melanomas, r=0.98, P<0.001 for nevi). Thickness measurements were possible for 23 of 26 cases for nevi and all (6) cases for melanoma. Our results show that handheld, linear-array PAI is highly reliable in measuring cutaneous lesion thickness in vivo, and can potentially be used to inform biopsy procedure and improve patient management.

Paper Details

Date Published: 13 February 2018
PDF: 7 pages
J. Med. Imag. 5(1) 015004 doi: 10.1117/1.JMI.5.1.015004
Published in: Journal of Medical Imaging Volume 5, Issue 1
Show Author Affiliations
Aedán Breathnach, National Univ. of Ireland, Galway (Ireland)
Elizabeth Concannon, Galway Univ. Hospitals (Ireland)
Jemima J. Dorairaj, Galway Univ. Hospitals (Ireland)
Shazrinizam Shaharan, Galway Univ. Hospitals (Ireland)
James McGrath, National Univ. of Ireland, Galway (Ireland)
Jithin Jose, FUJIFILM VisualSonics, Inc. (Netherlands)
Jack L. Kelly, Galway Univ. Hospitals (Ireland)
Martin J. Leahy, National Univ. of Ireland, Galway (Ireland)
Royal College of Surgeons in Ireland (Ireland)


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