Share Email Print
cover

Journal of Medical Imaging • new

7T MRI subthalamic nucleus atlas for use with 3T MRI
Author(s): Mikhail Milchenko; Scott A. Norris; Kathleen L. Poston; Meghan C. Campbell; Mwiza Ushe; Joel S. Perlmutter; Abraham Z. Snyder
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in most patients with Parkinson disease (PD), yet may produce untoward effects. Investigation of DBS effects requires accurate localization of the STN, which can be difficult to identify on magnetic resonance images collected with clinically available 3T scanners. The goal of this study is to develop a high-quality STN atlas that can be applied to standard 3T images. We created a high-definition STN atlas derived from seven older participants imaged at 7T. This atlas was nonlinearly registered to a standard template representing 56 patients with PD imaged at 3T. This process required development of methodology for nonlinear multimodal image registration. We demonstrate mm-scale STN localization accuracy by comparison of our 3T atlas with a publicly available 7T atlas. We also demonstrate less agreement with an earlier histological atlas. STN localization error in the 56 patients imaged at 3T was less than 1 mm on average. Our methodology enables accurate STN localization in individuals imaged at 3T. The STN atlas and underlying 3T average template in MNI space are freely available to the research community. The image registration methodology developed in the course of this work may be generally applicable to other datasets.

Paper Details

Date Published: 8 January 2018
PDF: 12 pages
J. Med. Imag. 5(1) 015002 doi: 10.1117/1.JMI.5.1.015002
Published in: Journal of Medical Imaging Volume 5, Issue 1
Show Author Affiliations
Mikhail Milchenko, Mallinckrodt Institute of Radiology (United States)
Scott A. Norris, Washington Univ. School of Medicine in St. Louis (United States)
Kathleen L. Poston, Stanford Univ. (United States)
Meghan C. Campbell, Washington Univ. School of Medicine in St. Louis (United States)
Mwiza Ushe, Washington Univ. School of Medicine in St. Louis (United States)
Joel S. Perlmutter, Washington Univ. School of Medicine in St. Louis (United States)
Abraham Z. Snyder, Washington Univ. School of Medicine in St. Louis (United States)


© SPIE. Terms of Use
Back to Top