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Journal of Medical Imaging

Use of clinical MRI maximum intensity projections for improved breast lesion classification with deep convolutional neural networks
Author(s): Natalia O. Antropova; Hiroyuki Abe; Maryellen L. Giger
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Paper Abstract

Deep learning methods have been shown to improve breast cancer diagnostic and prognostic decisions based on selected slices of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). However, incorporation of volumetric and temporal components into DCE-MRIs has not been well studied. We propose maximum intensity projection (MIP) images of subtraction MRI as a way to simultaneously include four-dimensional (4-D) images into lesion classification using convolutional neural networks (CNN). The study was performed on a dataset of 690 cases. Regions of interest were selected around each lesion on three MRI presentations: (i) the MIP image generated on the second postcontrast subtraction MRI, (ii) the central slice of the second postcontrast MRI, and (iii) the central slice of the second postcontrast subtraction MRI. CNN features were extracted from the ROIs using pretrained VGGNet. The features were utilized in the training of three support vector machine classifiers to characterize lesions as malignant or benign. Classifier performances were evaluated with fivefold cross-validation and compared based on area under the ROC curve (AUC). The approach using MIPs [AUC=0.88(se=0.01)] outperformed that using central-slices of either second postcontrast MRIs [0.80(se=0.02)] or second postcontrast subtraction MRIs [AUC=0.84(se=0.02)], at statistically significant levels.

Paper Details

Date Published: 5 February 2018
PDF: 6 pages
J. Med. Imag. 5(1) 014503 doi: 10.1117/1.JMI.5.1.014503
Published in: Journal of Medical Imaging Volume 5, Issue 1
Show Author Affiliations
Natalia O. Antropova, The Univ. of Chicago (United States)
Hiroyuki Abe, The Univ. of Chicago (United States)
Maryellen L. Giger, The Univ. of Chicago (United States)

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