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Journal of Medical Imaging • Open Access

Quantitative bone scan lesion area as an early surrogate outcome measure indicative of overall survival in metastatic prostate cancer
Author(s): Matthew S. Brown; Hyun J. Grace Kim; Gregory H. Chu; Bharath Ramakrishna; Martin Allen-Auerbach; Cheryce P. Fischer; Benjamin Levine; Pawan K. Gupta; Christiaan W. Schiepers; Jonathan G. Goldin

Paper Abstract

A clinical validation of the bone scan lesion area (BSLA) as a quantitative imaging biomarker was performed in metastatic castration-resistant prostate cancer (mCRPC). BSLA was computed from whole-body bone scintigraphy at baseline and week 12 posttreatment in a cohort of 198 mCRPC subjects (127 treated and 71 placebo) from a clinical trial involving a different drug from the initial biomarker development. BSLA computation involved automated image normalization, lesion segmentation, and summation of the total area of segmented lesions on bone scan AP and PA views as a measure of tumor burden. As a predictive biomarker, treated subjects with baseline BSLA < 200    cm 2 had longer survival than those with higher BSLA ( HR = 0.4 and p < 0.001 ). As a surrogate outcome biomarker, subjects were categorized as progressive disease (PD) if the BSLA increased by a prespecified 30% or more from baseline to week 12 and non-PD otherwise. Overall survival rates between PD and non-PD groups were statistically different ( HR = 0.64 and p = 0.007 ). Subjects without PD at week 12 had longer survival than subjects with PD: median 398 days versus 280 days. BSLA has now been demonstrated to be an early surrogate outcome for overall survival in different prostate cancer drug treatments.

Paper Details

Date Published: 11 January 2018
PDF: 6 pages
J. Med. Imag. 5(1) 011017 doi: 10.1117/1.JMI.5.1.011017
Published in: Journal of Medical Imaging Volume 5, Issue 1
Show Author Affiliations
Matthew S. Brown, Univ. of California, Los Angeles (United States)
Hyun J. Grace Kim, Univ. of California, Los Angeles (United States)
Gregory H. Chu, Univ. of California, Los Angeles (United States)
Bharath Ramakrishna, Univ. of California, Los Angeles (United States)
Martin Allen-Auerbach, Univ. of California, Los Angeles (United States)
Cheryce P. Fischer, Univ. of California, Los Angeles (United States)
Benjamin Levine, Univ. of California, Los Angeles (United States)
Pawan K. Gupta, Univ. of California, Los Angeles (United States)
Christiaan W. Schiepers, Univ. of California, Los Angeles (United States)
Jonathan G. Goldin, Univ. of California, Los Angeles (United States)


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