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Journal of Medical Imaging • Open Access

Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients
Author(s): Finbarr O’Sullivan; Janet N. O'Sullivan; Jian Huang; Robert Doot; Mark Muzi; Erin Schubert; Lanell Peterson; Lisa K. Dunnwald; David M. Mankoff

Paper Abstract

Blood flow-metabolism mismatch from dynamic positron emission tomography (PET) studies with O 15 -labeled water ( H 2 O ) and F 18 -labeled fluorodeoxyglucose (FDG) has been shown to be a promising diagnostic for locally advanced breast cancer (LABCa) patients. The mismatch measurement involves kinetic analysis with the arterial blood time course (AIF) as an input function. We evaluate the use of a statistical method for AIF extraction (SAIF) in these studies. Fifty three LABCa patients had dynamic PET studies with H 2 O and FDG. For each PET study, two AIFs were recovered, an SAIF extraction and also a manual extraction based on a region of interest placed over the left ventricle (LV-ROI). Blood flow-metabolism mismatch was obtained with each AIF, and kinetic and prognostic reliability comparisons were made. Strong correlations were found between kinetic assessments produced by both AIFs. SAIF AIFs retained the full prognostic value, for pathologic response and overall survival, of LV-ROI AIFs.

Paper Details

Date Published: 23 November 2017
PDF: 9 pages
J. Med. Imag. 5(1) 011010 doi: 10.1117/1.JMI.5.1.011010
Published in: Journal of Medical Imaging Volume 5, Issue 1
Show Author Affiliations
Finbarr O’Sullivan, Univ. College Cork (Ireland)
Janet N. O'Sullivan, Univ. College Cork (Ireland)
Jian Huang, Univ. College Cork (Ireland)
Robert Doot, Univ. of Pennsylvania (United States)
Mark Muzi, Univ. of Washington (United States)
Erin Schubert, Univ. of Pennsylvania (United States)
Lanell Peterson, Univ. of Washington (United States)
Lisa K. Dunnwald, The Univ. of Iowa (United States)
David M. Mankoff, Univ. of Pennsylvania (United States)

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