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Journal of Medical Imaging

Phase-contrast imaging with a compact x-ray light source: system design
Author(s): Yongjin Sung; Rajiv Gupta; Brandon Nelson; Shuai Leng; Cynthia H. McCollough; William S. Graves
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Paper Abstract

X-ray phase-contrast imaging (XPCI) overcomes the problem of low contrast between different soft tissues achieved in conventional x-ray imaging by introducing x-ray phase as an additional contrast mechanism. This work describes a compact x-ray light source (CXLS) and compares, via simulations, the high quality XPCI results that can be produced from this source to those produced using a microfocus x-ray source. The simulation framework is first validated using an image acquired with a microfocus-source, propagation-based XPCI (PB-XPCI) system. The phase contrast for a water sphere simulating a simple cyst submersed in muscle is evaluated and the evolution of PB-XPCI signal as the object to detector distance is increased is demonstrated. The proposed design of a PB-XPCI system using the CXLS is described and simulated images of a coronary artery compared between CXLS and microfocus source PB-XPCI systems. To generate images with similar noise levels, a microfocus source would require a 3000 times longer exposure than would the CXLS. We conclude that CXLS technology has the potential to provide high-quality XPCI in a medical environment using extremely short exposure times relative to microfocus source approaches.

Paper Details

Date Published: 23 November 2017
PDF: 9 pages
J. Med. Imag. 4(4) 043503 doi: 10.1117/1.JMI.4.4.043503
Published in: Journal of Medical Imaging Volume 4, Issue 4
Show Author Affiliations
Yongjin Sung, Univ. of Wisconsin-Milwaukee (United States)
Rajiv Gupta, Massachusetts General Hospital (United States)
Brandon Nelson, Mayo Clinic (United States)
Shuai Leng, Mayo Clinic (United States)
Cynthia H. McCollough, Mayo Clinic (United States)
William S. Graves, Arizona State Univ. (United States)

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