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Journal of Medical Imaging

Noninvasive radiomics signature based on quantitative analysis of computed tomography images as a surrogate for microvascular invasion in hepatocellular carcinoma: a pilot study
Author(s): Shaimaa H. Bakr; Sebastian Echegaray; Rajesh P. Shah; Aya Kamaya; John Louie; Sandy Napel; Nishita Kothary; Olivier Gevaert
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Paper Abstract

We explore noninvasive biomarkers of microvascular invasion (mVI) in patients with hepatocellular carcinoma (HCC) using quantitative and semantic image features extracted from contrast-enhanced, triphasic computed tomography (CT). Under institutional review board approval, we selected 28 treatment-naive HCC patients who underwent surgical resection. Four radiologists independently selected and delineated tumor margins on three axial CT images and extracted computational features capturing tumor shape, image intensities, and texture. We also computed two types of “delta features,” defined as the absolute difference and the ratio computed from all pairs of imaging phases for each feature. 717 arterial, portal-venous, delayed single-phase, and delta-phase features were robust against interreader variability (concordance correlation≥0.8). An enhanced cross-validation analysis showed that combining robust single-phase and delta features in the arterial and venous phases identified mVI (AUC 0.76±0.18). Compared to a previously reported semantic feature signature (AUC 0.47 to 0.58), these features in our cohort showed only slight to moderate agreement (Cohen’s kappa range: 0.03 to 0.59). Though preliminary, quantitative analysis of image features in arterial and venous phases may be potential surrogate biomarkers for mVI in HCC. Further study in a larger cohort is warranted.

Paper Details

Date Published: 21 August 2017
PDF: 8 pages
J. Med. Imag. 4(4) 041303 doi: 10.1117/1.JMI.4.4.041303
Published in: Journal of Medical Imaging Volume 4, Issue 4
Show Author Affiliations
Shaimaa H. Bakr, Stanford Univ. (United States)
Sebastian Echegaray, Stanford Univ. (United States)
Rajesh P. Shah, Stanford Univ. (United States)
Aya Kamaya, Stanford Univ. (United States)
John Louie, Stanford Univ. (United States)
Sandy Napel, Stanford Univ. School of Medicine (United States)
Nishita Kothary, Stanford Univ. (United States)
Olivier Gevaert, Stanford Univ. (United States)

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