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Journal of Medical Imaging

INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy
Author(s): Maria Giuseppina Bisogni; Andrea Attili; Giuseppe Battistoni; Nicola Belcari; Niccolo’ Camarlinghi; Piergiorgio Cerello; Silvia Coli; Alberto Del Guerra; Alfredo Ferrari; Veronica Ferrero; Elisa Fiorina; Giuseppe Giraudo; Eleftheria Kostara; Matteo Morrocchi; Francesco Pennazio; Cristiana Peroni; Maria Antonietta Piliero; Giovanni Pirrone; Angelo Rivetti; Manuel D. Rolo; Valeria Rosso; Paola Sala; Giancarlo Sportelli; Richard Wheadon
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Paper Abstract

The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. In 2013, the Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal imaging concept that combines an in-beam PET scanner with a tracking system for charged particle imaging. This paper presents the general architecture of the INSIDE project but focuses on the in-beam PET scanner that has been designed to reconstruct the particles range with millimetric resolution within a fraction of the dose delivered in a treatment of head and neck tumors. The in-beam PET scanner has been recently installed at the Italian National Center of Oncologic Hadrontherapy (CNAO) in Pavia, Italy, and the commissioning phase has just started. The results of the first beam test with clinical proton beams on phantoms clearly show the capability of the in-beam PET to operate during the irradiation delivery and to reconstruct on-line the beam-induced activity map. The accuracy in the activity distal fall-off determination is millimetric for therapeutic doses.

Paper Details

Date Published: 2 December 2016
PDF: 12 pages
J. Med. Img. 4(1) 011005 doi: 10.1117/1.JMI.4.1.011005
Published in: Journal of Medical Imaging Volume 4, Issue 1
Show Author Affiliations
Maria Giuseppina Bisogni, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Andrea Attili, Univ. degli Studi di Torino (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Giuseppe Battistoni, Istituto Nazionale di Fisica Nucleare (Italy)
Nicola Belcari, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Niccolo’ Camarlinghi, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Piergiorgio Cerello, Istituto Nazionale di Fisica Nucleare (Italy)
Silvia Coli, Istituto Nazionale di Fisica Nucleare (Italy)
Alberto Del Guerra, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Alfredo Ferrari, CERN (Switzerland)
Veronica Ferrero, Univ. degli Studi di Torino (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Elisa Fiorina, Istituto Nazionale di Fisica Nucleare (Italy)
Giuseppe Giraudo, Istituto Nazionale Fisica Nucleare INFN (Italy)
Eleftheria Kostara, Istituto Nazionale di Fisica Nucleare (Italy)
Matteo Morrocchi, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Francesco Pennazio, Istituto Nazionale di Fisica Nucleare (Italy)
Cristiana Peroni, Univ. degli Studi di Torino (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Maria Antonietta Piliero, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Giovanni Pirrone, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Angelo Rivetti, Istituto Nazionale di Fisica Nucleare (Italy)
Manuel D. Rolo, Istituto Nazionale di Fisica Nucleare (Italy)
Valeria Rosso, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Paola Sala, Istituto Nazionale di Fisica Nucleare (Italy)
Giancarlo Sportelli, Univ. di Pisa (Italy)
Istituto Nazionale Fisica Nucleare (Italy)
Richard Wheadon, Istituto Nazionale di Fisica Nucleare (Italy)


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