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Journal of Medical Imaging

Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer
Author(s): Nicholas Whiting; Jingzhe Hu; Niki M. Zacharias; Ganesh L. R. Lokesh; David E. Volk; David G. Menter; Rajesha Rupaimoole; Rebecca Previs; Anil K. Sood; Pratip Bhattacharya
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Paper Abstract

Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging. The enhanced spin polarization of silicon lasts significantly longer than other hyperpolarized agents (tens of minutes, whereas <1  min for other species at room temperature), allowing a wide range of potential applications. We report our recent characterizations of hyperpolarized silicon particles, with the ultimate goal of targeted, noninvasive, and nonradioactive molecular imaging of various cancer systems. A variety of particle sizes (20 nm to 2  μm) were found to have hyperpolarized relaxation times ranging from ∼10 to 50 min. The addition of various functional groups to the particle surface had no effect on the hyperpolarization buildup or decay rates and allowed in vivo imaging over long time scales. Additional in vivo studies examined a variety of particle administration routes in mice, including intraperitoneal injection, rectal enema, and oral gavage.

Paper Details

Date Published: 10 August 2016
PDF: 9 pages
J. Med. Img. 3(3) 036001 doi: 10.1117/1.JMI.3.3.036001
Published in: Journal of Medical Imaging Volume 3, Issue 3
Show Author Affiliations
Nicholas Whiting, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jingzhe Hu, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rice Univ. (United States)
Niki M. Zacharias, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Ganesh L. R. Lokesh, The Univ. of Texas Health Science Ctr. at Houston (United States)
David E. Volk, The Univ. of Texas Health Science Ctr. at Houston (United States)
David G. Menter, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rajesha Rupaimoole, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rebecca Previs, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Anil K. Sood, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Pratip Bhattacharya, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


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