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Journal of Medical Imaging

Fat-water MRI of a diet-induced obesity mouse model at 15.2T
Author(s): Henry H. Ong; Corey D. Webb; Marnie L. Gruen; Alyssa H. Hasty; John C. Gore; E. Brian Welch
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Paper Abstract

Quantitative fat-water MRI (FWMRI) methods provide valuable information about the distribution, volume, and composition of adipose tissue (AT). Ultra high field FWMRI of animal models may have the potential to provide insights into the progression of obesity and its comorbidities. Here, we present quantitative FWMRI with all known confounder corrections on a 15.2T preclinical scanner for noninvasive in vivo monitoring of an established diet-induced obesity mouse model. Male C57BL/6J mice were placed on a low-fat (LFD) or a high-fat diet (HFD). Three-dimensional (3-D) multiple gradient echo MRI at 15.2T was performed at baseline, 4, 8, 12, and 16 weeks after diet onset. A 3-D fat-water separation algorithm and additional processing were used to generate proton-density fat fraction (PDFF), local magnetic field offset, and R*2 maps. We examined these parameters in perirenal AT ROIs from LFD and HFD mice. The data suggest that PDFF, local field offset, and R*2 have different time course behaviors between LFD and HFD mice over 16 weeks. This work suggests FWMRI at 15.2T may be a useful tool for longitudinal studies of adiposity due to the advantages of ultra high field although further investigation is needed to understand the observed time course behavior.

Paper Details

Date Published: 24 May 2016
PDF: 7 pages
J. Med. Img. 3(2) 026002 doi: 10.1117/1.JMI.3.2.026002
Published in: Journal of Medical Imaging Volume 3, Issue 2
Show Author Affiliations
Henry H. Ong, Vanderbilt Univ. (United States)
Corey D. Webb, Vanderbilt Univ. (United States)
Marnie L. Gruen, Vanderbilt Univ. (United States)
Alyssa H. Hasty, Vanderbilt Univ. (United States)
John C. Gore, Vanderbilt Univ. Medical Ctr. (United States)
E. Brian Welch, Vanderbilt Univ. (United States)


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