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Journal of Medical Imaging

Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
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Paper Abstract

Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame averaging. There was no effect of tissue depth or oblique imaging on pullback parameter estimates. The method’s performance was assessed in comparison with observer-defined standards using clinical pullback data. Values (calcium 3.58±1.74  mm1, lipid 9.93±2.44  mm1, and fibrous 1.96±1.11 mm1) were consistent with previous measurements obtained by other means. Using optical parameters (μt, 〈I〉, I0), we achieved feature space separation of plaque types and classification accuracy of 92.5±3%. Despite the rapid z motion and varying incidence angle in pullbacks, the proposed computational pipeline appears to work as well as a more standard “stationary” approach.

Paper Details

Date Published: 13 May 2016
PDF: 9 pages
J. Med. Imag. 3(2) 024501 doi: 10.1117/1.JMI.3.2.024501
Published in: Journal of Medical Imaging Volume 3, Issue 2
Show Author Affiliations
Ronny Y. Shalev, Case Western Reserve Univ. (United States)
Madhusudhana Gargesha, Case Western Reserve Univ. (United States)
David Prabhu, Case Western Reserve Univ. (United States)
Kentaro Tanaka, Univ. Hospitals Case Medical Ctr. (United States)
Andrew M. Rollins, Case Western Reserve Univ. (United States)
Guy Lamouche, National Research Council Canada (Canada)
Charles-Etienne Bisaillon, National Research Council Canada (Canada)
Hiram G. Bezerra, Univ. Hospitals Case Medical Ctr. (United States)
Soumya Ray, Case Western Reserve Univ. (United States)
David L. Wilson, Case Western Reserve Univ. (United States)

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