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Journal of Medical Imaging

Bolus arrival time and its effect on tissue characterization with dynamic contrast-enhanced magnetic resonance imaging
Author(s): Alireza Mehrtash; Sandeep N. Gupta; Dattesh Shanbhag; James V. Miller; Tina Kapur; Fiona M. Fennessy; Ron Kikinis; Andriy Fedorov
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Paper Abstract

Matching the bolus arrival time (BAT) of the arterial input function (AIF) and tissue residue function (TRF) is necessary for accurate pharmacokinetic (PK) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We investigated the sensitivity of volume transfer constant (Ktrans) and extravascular extracellular volume fraction (ve) to BAT and compared the results of four automatic BAT measurement methods in characterization of prostate and breast cancers. Variation in delay between AIF and TRF resulted in a monotonous change trend of Ktrans and ve values. The results of automatic BAT estimators for clinical data were all comparable except for one BAT estimation method. Our results indicate that inaccuracies in BAT measurement can lead to variability among DCE-MRI PK model parameters, diminish the quality of model fit, and produce fewer valid voxels in a region of interest. Although the selection of the BAT method did not affect the direction of change in the treatment assessment cohort, we suggest that BAT measurement methods must be used consistently in the course of longitudinal studies to control measurement variability.

Paper Details

Date Published: 1 March 2016
PDF: 16 pages
J. Med. Imag. 3(1) 014503 doi: 10.1117/1.JMI.3.1.014503
Published in: Journal of Medical Imaging Volume 3, Issue 1
Show Author Affiliations
Alireza Mehrtash, Brigham and Women’s Hospital (United States)
Harvard Medical School (United States)
Sandeep N. Gupta, GE Global Research (United States)
Dattesh Shanbhag, GE India Technology Centre Pvt. Ltd. (India)
James V. Miller, GE Global Research (United States)
Tina Kapur, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Fiona M. Fennessy, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Dana Farber Cancer Institute (United States)
Ron Kikinis, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)
Andriy Fedorov, Brigham and Women's Hospital (United States)
Harvard Medical School (United States)


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