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Journal of Medical Imaging • Open Access

Volumetric limiting spatial resolution analysis of four-dimensional digital subtraction angiography

Paper Abstract

C-Arm CT three-dimensional (3-D) digital subtraction angiography (DSA) reconstructions cannot provide temporal information to radiologists. Four-dimensional (4-D) DSA provides a time series of 3-D volumes utilizing temporal dynamics in the two-dimensional (2-D) projections using a constraining image reconstruction approach. Volumetric limiting spatial resolution (VLSR) of 4-D DSA is quantified and compared to a 3-D DSA. The effects of varying 4-D DSA parameters of 2-D projection blurring kernel size and threshold of the 3-D DSA (constraining image) of an in silico phantom (ISPH) and physical phantom (PPH) were investigated. The PPH consisted of a 76-micron tungsten wire. An 8-s/248-frame/198-deg scan protocol acquired the projection data. VLSR was determined from MTF curves generated from each 2-D transverse slice of every (248) 4-D temporal frame. 4-D DSA results for PPH and ISPH were compared to the 3-D DSA. 3-D DSA analysis resulted in a VLSR of 2.28 and 1.69  lp/mm for ISPH and PPH, respectively. Kernel sizes of either 10×10 or 20×20  pixels with a 3-D DSA constraining image threshold of 10% provided 4-D DSA VLSR nearest to the 3-D DSA. 4-D DSA yielded 2.21 and 1.67  lp/mm with a percent error of 3.1 and 1.2% for ISPH and PPH, respectively, as compared to 3-D DSA. This research indicates 4-D DSA is capable of retaining the resolution of 3-D DSA.

Paper Details

Date Published: 25 January 2016
PDF: 9 pages
J. Med. Imag. 3(1) 013503 doi: 10.1117/1.JMI.3.1.013503
Published in: Journal of Medical Imaging Volume 3, Issue 1
Show Author Affiliations
Brian J. Davis, Univ. of Wisconsin-Madison (United States)
Erick Oberstar, Univ. of Wisconsin-Madison (United States)
Kevin Royalty, Univ. of Wisconsin-Madison (United States)
Siemens Medical Solutions (United States)
Sebastian Schafer, Siemens Medical Solutions USA, Inc. (United States)
Charles Mistretta, Univ. of Wisconsin-Madison (United States)

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